Research Articles
The Sugar Paintbrush: How Scientists Decoded the Enzyme That Initiates Mucin Biosynthesis
Discover how scientists uncovered the crystal structure of ppGaNTase-T1, the enzyme that initiates mucin biosynthesis, revealing the molecular machinery that builds our protective mucus layers.
The Unexpected Ally in Our Soil: How a Fungus-Fighting Enzyme Could Revolutionize Medicine
Discover how PolB, an unusual UMP C-5 methylase in polyoxin biosynthesis, could revolutionize antibiotic development and fight drug-resistant infections.
The Positive Charge: How a Sulfonium Atom Guides a Key Cellular Enzyme
Exploring how the sulfonium center in S-adenosylmethionine determines ligand specificity in human AdoMetDC enzyme and its therapeutic implications
The Radical Enzyme: How Ribonucleotide Reductase Builds the Blueprint of Life
Explore the fascinating world of ribonucleotide reductase, the essential enzyme that converts RNA building blocks into DNA and controls cell division.
The Cofactor-Free Miracle: How Nature Crafts Vancomycin
Exploring the remarkable enzyme DpgC that performs cofactor-independent dioxygenation in vancomycin biosynthesis, our last line of defense against superbugs.
The Hidden Architect of Cannabis: How a Tiny Enzyme Builds THC's Molecular Foundation
Discover how olivetolic acid cyclase (OAC), a remarkable enzyme in cannabis, creates the foundation for THC, CBD, and other cannabinoids through groundbreaking structural biology research.
Unlocking the Body's Chemical Factory: The Tiny Scissors in Your Liver
Discover how scientists mapped the atomic structure of AKR1D1 enzyme, revealing insights into hormone metabolism and potential treatments for related diseases.
Nature's Molecular Origami: How Quinoa Reinvented a Chemical Masterpiece
Discover how quinoa's 2,3-oxidosqualene cyclase enzyme creates rare B,C-ring-opened triterpenes through evolutionary innovation
The Cell's Secret Assassin and the Radical Iron-Sulfur Enzyme That Saves It
Discover how diphthamide biosynthesis uses radical-based biochemistry and iron-sulfur enzymes to protect cellular protein synthesis from toxins.
Nature's Molecular Sculptor: How a Key Plant Enzyme Crafts Growth Hormones
Discover how ent-copalyl diphosphate synthase catalyzes gibberellin biosynthesis through innovative mechanistic analysis revealing novel product chemistry.